Neurons in vulnerable regions of the Alzheimer's disease brain display reduced ATM signaling1,2,3
نویسندگان
چکیده
Xuting Shen, Jianmin Chen, Jiali Li, Julia Kofler and Karl Herrup Division of Life Science and State Key Laboratory of Molecular Neurobiology Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong Department of Cell Biology and Neuroscience, Rutgers University, 604 Allison Road, Piscataway, NJ 08854, USA Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, 650223, China Department of Pathology and, The Alzheimer's Disease Research Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA Department of Otolaryngology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
منابع مشابه
Neurons in Vulnerable Regions of the Alzheimer's Disease Brain Display Reduced ATM Signaling.
Ataxia telangiectasia (A-T) is a multisystemic disease caused by mutations in the ATM (A-T mutated) gene. It strikes before 5 years of age and leads to dysfunctions in many tissues, including the CNS, where it leads to neurodegeneration, primarily in cerebellum. Alzheimer's disease (AD), by contrast, is a largely sporadic neurodegenerative disorder that rarely strikes before the 7th decade of l...
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